It really depends on the type of roads that you are going to ride. I've had days of not doing more than about 200 miles of twisties and been worn out. I've done an iron butt in 18 hours and still felt good.
On my trip to WV, we rode nothing but 2 lanes. We did 290, 320, 330, and 325. We generally left by 9:30 and arrived by 6:00.
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